10 results
Clinical predictors of conversion to bipolar disorder in a prospective longitudinal familial high-risk sample: focus on depressive features
- Andrew Frankland, Gloria Roberts, Ellen Holmes-Preston, Tania Perich, Florence Levy, Rhoshel Lenroot, Dusan Hadzi-Pavlovic, Michael Breakspear, Philip B. Mitchell
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- Journal:
- Psychological Medicine / Volume 48 / Issue 10 / July 2018
- Published online by Cambridge University Press:
- 07 November 2017, pp. 1713-1721
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Background
Identifying clinical features that predict conversion to bipolar disorder (BD) in those at high familial risk (HR) would assist in identifying a more focused population for early intervention.
MethodIn total 287 participants aged 12–30 (163 HR with a first-degree relative with BD and 124 controls (CONs)) were followed annually for a median of 5 years. We used the baseline presence of DSM-IV depressive, anxiety, behavioural and substance use disorders, as well as a constellation of specific depressive symptoms (as identified by the Probabilistic Approach to Bipolar Depression) to predict the subsequent development of hypo/manic episodes.
ResultsAt baseline, HR participants were significantly more likely to report ⩾4 Probabilistic features (40.4%) when depressed than CONs (6.7%; p < .05). Nineteen HR subjects later developed either threshold (n = 8; 4.9%) or subthreshold (n = 11; 6.7%) hypo/mania. The presence of ⩾4 Probabilistic features was associated with a seven-fold increase in the risk of ‘conversion’ to threshold BD (hazard ratio = 6.9, p < .05) above and beyond the fourteen-fold increase in risk related to major depressive episodes (MDEs) per se (hazard ratio = 13.9, p < .05). Individual depressive features predicting conversion were psychomotor retardation and ⩾5 MDEs. Behavioural disorders only predicted conversion to subthreshold BD (hazard ratio = 5.23, p < .01), while anxiety and substance disorders did not predict either threshold or subthreshold hypo/mania.
ConclusionsThis study suggests that specific depressive characteristics substantially increase the risk of young people at familial risk of BD going on to develop future hypo/manic episodes and may identify a more targeted HR population for the development of early intervention programs.
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. 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Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
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- By Francesco Acerbi, Ayca Akgoz, Matthew R. Amans, Ramsey Ashour, Mohammed Ali Aziz-Sultan, H. Hunt Batjer, Donnie Bell, Bernard R. Bendok, Giovanni Broggi, Morgan Broggi, Charles A. Bruno, Steven D. Chang, In Sup Choi, Omar Choudhri, Douglas J. Cook, William P. Dillon, Peter Dirks, Rose Du, Travis M. Dumont, Tarek Y. El Ahmadieh, Najib E. El Tecle, Mohamed Samy Elhammady, Paolo Ferroli, Alana M. Flexman, John C. Flickinger, Kai U. Frerichs, Sasikhan Geibprasert, Adrian W. Gelb, Y. Pierre Gobin, Bradley A. Gross, Seunggu J. Han, Tomoki Hashimoto, Juha Hernesniemi, Roberto C. Heros, Steven W. Hetts, Randall T. Higashida, Joshua A. Hirsch, Nikolai J. Hopf, L. Nelson Hopkins, Maziyar A. Kalani, M. Yashar S. Kalani, Hideyuki Kano, Syed Aftab Karim, Robert M. Koffie, Douglas S. Kondziolka, Timo Krings, Aki Laakso, Giuseppe Lanzino, Michael T. Lawton, Elad I. Levy, L. Dade Lunsford, Adel M. Malek, Michael P. Marks, George A. C. Mendes, Philip M. Meyers, Jacques Morcos, Nitin Mukerji, Christian Musahl, Ludmila Pawlikowska, Matthew B. Potts, Ross Puffer, James D. Rabinov, Jonathan J. Russin, Mina G. Safain, Duke Samson, Marco Schiariti, R. Michael Scott, Jason P. Sheehan, Paul Singh, Edward R. Smith, Scott G. Soltys, Robert F. Spetzler, Gary K. Steinberg, Philip E. Stieg, Hua Su, Karel terBrugge, Kiron Thomas, Tarik Tihan, Babu Welch, Jonathan White, H. Richard Winn, Chun-Po Yen, Jacky T. Yeung, Byron Yip, Samer G. Zammar
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- Trauma
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- By Waiel Almoustadi, Brian J. Anderson, David B. Auyong, Michael Avidan, Michael J. Avram, Roland J. Bainton, Jeffrey R. Balser, Juliana Barr, W. Scott Beattie, Manfred Blobner, T. Andrew Bowdle, Walter A. Boyle, Eugene B. Campbell, Laura F. Cavallone, Mario Cibelli, C. Michael Crowder, Ola Dale, M. Frances Davies, Mark Dershwitz, George Despotis, Clifford S. Deutschman, Brian S. Donahue, Marcel E. Durieux, Thomas J. Ebert, Talmage D. Egan, Helge Eilers, E. Wesley Ely, Charles W. Emala, Alex S. Evers, Heidrun Fink, Pierre Foëx, Stuart A. Forman, Helen F. Galley, Josephine M. Garcia-Ferrer, Robert W. Gereau, Tony Gin, David Glick, B. Joseph Guglielmo, Dhanesh K. Gupta, Howard B. Gutstein, Robert G. Hahn, Greg B. Hammer, Brian P. Head, Helen Higham, Laureen Hill, Kirk Hogan, Charles W. Hogue, Christopher G. Hughes, Eric Jacobsohn, Roger A. Johns, Dean R. Jones, Max Kelz, Evan D. Kharasch, Ellen W. King, W. Andrew Kofke, Tom C. Krejcie, Richard M. Langford, H. T. Lee, Isobel Lever, Jerrold H. Levy, J. Lance Lichtor, Larry Lindenbaum, Hung Pin Liu, Geoff Lockwood, Alex Macario, Conan MacDougall, M. B. MacIver, Aman Mahajan, Nándor Marczin, J. A. Jeevendra Martyn, George A. Mashour, Mervyn Maze, Thomas McDowell, Stuart McGrane, Berend Mets, Patrick Meybohm, Charles F. Minto, Jonathan Moss, Mohamed Naguib, Istvan Nagy, Nick Oliver, Paul S. Pagel, Pratik P. Pandharipande, Piyush Patel, Andrew J. Patterson, Robert A. Pearce, Ronald G. Pearl, Misha Perouansky, Kristof Racz, Chinniampalayam Rajamohan, Nilesh Randive, Imre Redai, Stephen Robinson, Richard W. Rosenquist, Carl E. Rosow, Uwe Rudolph, Francis V. Salinas, Robert D. Sanders, Sunita Sastry, Michael Schäfer, Jens Scholz, Thomas W. Schnider, Mark A. Schumacher, John W. Sear, Frédérique S. Servin, Jeffrey H. Silverstein, Tom De Smet, Martin Smith, Joe Henry Steinbach, Markus Steinfath, David F. Stowe, Gary R. Strichartz, Michel M. R. F. Struys, Isao Tsuneyoshi, Robert A. Veselis, Arthur Wallace, Robert P. Walt, David C. Warltier, Nigel R. Webster, Jeanine Wiener-Kronish, Troy Wildes, Paul Wischmeyer, Ling-Gang Wu, Stephen Yang
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Illiberal Liberalism: The New Property as Strategy
- Michael B. Levy
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- The Review of Politics / Volume 45 / Issue 4 / October 1983
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- 05 August 2009, pp. 576-594
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In the decade spanning 1968 to 1978, the Supreme Court cited the concept of the “new property” in over forty cases concerning the rights of clients in public sector relationships. The term new property first appeared in two law review articles written by Charles Reich in 1964 and 1965, and its primary points have since found favor with a number of political theorists. At the heart of the “new property” idea was the belief that a great many public sector benefits performed traditional functions of property and, therefore, ought to have been redefined as property in the law. Accordingly, Reich argued that public sector grants, including public assistance as well as unemployment compensation and Social Security, should lose their legal status as gratuities or charitable gifts and become instead “property” with all of the constitutional guarantees of due process that adhere to property in our system. This was a most egalitarian project indeed, with implications that went far beyond extending rights of due process. By transforming all men and women into property owners regardless of their private assets, the “new property” paved the way for a political vocabulary which wedded the particular and exclusive language of property with the universal, all-inclusive language of egalitarianism. In most respects this redefinition simply would have expanded the egalitarian direction implicit in past liberal functionalist theories of property, developments which many had already approved.
Early Bronze Age metallurgy: a newly discovered copper manufactory in southern Jordan
- Thomas E. Levy, Russell B. Adams, Andreas Hauptmann, Michael Prange, Sigrid Schmitt-Strecker, Mohammad Najjar
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Recent excavations in southern Jordan have revealed the largest Early Bronze Age (c. 3600-2000 BC) metal manufactory in the ancient Near East. On-site Geographic Information Systems (GIS) analyses of the finds provide new evidence concerning the scale and organization of metal production at a time when the first cities emerged in this part of the Near East. Materials and lead isotope analyses of the metallurgical finds provide important data for reconstructing ancient metal processing and for identifying trade networks.
An open letter to the President
- Louis Appleby, Glyn Lewis, R. H. Cawley, Isaac Marks, Pamela Taylor, Raymond Levy, Klaus Bergmann, Nick Temple, Brian Toone, Stephen Wolkind, Eileen Joyce, Michael Gill, E. Guinness, Michael Farrell, V. L. Nimgaonkar, Deborah Chee, L. Mynors-Wallis, Peter Jones, Penny Thompson, Rachel Brown, H. Ring, Claire Gerada, Jenny Bearn, S. G. Potts, B. C. Beats, Lyn Pilowsky, Judith Jackson, G. F. Searle, Keith Lloyd, Helena Fox, Parimela Moodley, Tony Maden, S. W. Lewis, M. W. Orrell, D. Murphy, W. J. Levy, Brian Green, Alex Buchanan, Marian J. Perkins, Peter Misch, Gillian Mezey, M. Murphy, Anthony David, Robert Kerwin, Shirine Pezeshgi, M. Abas, P. Silverstone, J. H. Stone, G. O. 'Sullivan, R. Araya, R. Ball, E. Palazidou, Jane Milton, Anthony J. Pelosi, Janet Carrick, Dinesh Bhugra, Chris Hollis, Mark Berelowitz, N. R. Fisher, Deborah Brooke, Charles Hindler, Malcolm Battersby, Abigail Seltzer
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- Psychiatric Bulletin / Volume 12 / Issue 12 / December 1988
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- 02 January 2018, p. 554
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- December 1988
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